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M9480845.TXT
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1994-09-05
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Document 0845
DOCN M9480845
TI Association of HEp-2 cell adherent Escherichia coli with diarrhea among
adults infected with HIV.
DT 9410
AU Mathewson JJ; Jiang ZD; Luo N; Chintu C; Zumla A; DuPont HL; University
of Texas, Houston.
SO Abstr Gen Meet Am Soc Microbiol. 1994;94:544 (abstract no. C-303).
Unique Identifier : AIDSLINE ASM94/94313100
AB Both acute and chronic diarrhea are common problems in African patients
infected with the human immunodeficiency virus (HIV). There are many
different agents responsible for diarrhea in this population, but a
recognized cause is not found in most cases. We tested E. coli from
Zambians for adherence to HEp-2 cells. Among the 99 HIV+ patients: there
were 19 asymptomatic controls, 42 with acute diarrhea (< 72 hrs), and 38
with chronic diarrhea (> 30 days). Among the 15 HIV-patients, there were
3 asymptomatic controls and 6 with each acute and chronic diarrhea. E.
coli that adhered to HEp-2 cells were the most common enteropathogen
among the HIV+ patients with diarrhea. HEp-2 cell adherent E. coli were
identified significantly more frequently from all HIV+ individuals than
from the HIV-group (p < 0.01). Adherent E. coli were found more commonly
among HIV+ patients with acute diarrhea, than among the HIV+
asymptomatic controls (60% versus 37%) and significantly more often
among HIV+ patients with chronic diarrhea (79%) compared to HIV+
controls (p < 0.001). These organisms were also found significantly more
often in HIV+ patients with chronic diarrhea than among HIV-patients
with chronic diarrhea (p < 0.007). The different adherence patterns of
the adherence of strains isolated from the AIDS patients varied. None of
the locally adherent E. coli hybridized with the enteropathogenic E.
coli adherence factor (EAF) probe. Adherent E. coli strains may explain
a considerable portion of AIDS associated diarrhea in the African form
of the disease and deserve further study.
DE Acute Disease Adult AIDS-Related Opportunistic
Infections/*MICROBIOLOGY *Bacterial Adhesion Cell Line Chronic
Disease Comparative Study Diarrhea/EPIDEMIOLOGY/*MICROBIOLOGY
Escherichia coli/ISOLATION & PURIF/*PHYSIOLOGY Escherichia coli
Infections/*MICROBIOLOGY/PHYSIOPATHOLOGY Human HIV Seronegativity
*HIV Seropositivity Tumor Cells, Cultured MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).